Ohio State is 65-12-5 vs Indiana. They are 42-10-4 at home and 23-2-1 at Bloomington. The Buckeyes beat Navy 31-27 at home. The next week they lost a heart breaker to the USC Trojans at home in the last minutes 15-18. They Buckeyes come to Bloomington with two previous shutouts Blanking Toledo at Cleveland 38-0 and Illinois 30-0 at home. The lat time they had two shut outs back to back was 1996 blanking Minnesota 45-0 and Illinois 48-0. The last time OSU shut out Indiana was 10-18-97 31-0, in Columbus. The last time the Buckeyes shut out Indiana at Bloomington was 10-5-63 with the score being 21-0. The most points the Buckeyes have scored on Indiana is 56, they've done this twice, winning 56-0 in Columbus on 10-19-57 and 56-17 in Bloomington 56-17 on 11-5-1983. The Buckeyes gave up 41 points in a 41-7 in Bloomington on 10-8-88, while the worst loss at home was a32-10 loss in Columbus during Woody Hayes's first year on 10-20-51. After that game coach Hayes said, he would never lose to Indiana again. He kept his word going  22-1-1 all time against the Hoosiers.
Coach Tressel has an all time  6-0 record and is 3-0 on the road against Indiana. The last time these two teams hooked up OSU won 44-3 in Columbus, the last time these two Big Ten foes matched up in Bloomington OSU won 41-10.

With Kurt Coleman serving a one game suspension I don't believe the Bucks have a shot at the shut out, but they will only give up one TD pass very late in the game.  The offense keeps improving. Boom Herron not 100% Saine is going to start.
OSU wins 41-10.
(scroll down to other predictions)

Here are some Buckeye bests vs Indiana:

Rushing VS Indiana

224 yds @Home Calvin Murray 1980 good for 8th all time.
175 yds @Indiana Tim Spencer good for a tie at 23rd all time.

last time 3 backs with 100 yds Home vs Indiana        last time 2 backs with 100 yds Home vs Indiana        last time 2 backs 100yds @ IU
1956 Galen Cisco         160 yds                                1989 Carlos Snow      136 yds                               1973 Archie Griffin   130 yds
        James Roseboro  157 yds                                        Scottie Graham  124 yds                                       Bruce Elia       123 yds   
        Donald Clark       112 yds

Pass Receptions vs Indiana

13 catches by David Boston @ Indiana in 1996 good for 2nd all time

159 yds receiving by Dee Miller @ Indiana in 1998 good for 20th all time

25.5 yards average per catch 6-153 yds @ Indiana in 2003 good for 8th all time
 
last time 2 receivers with at least 100 yds @ Indiana
1998 Dee Miller     159 yds
        David Boston 110yds

Passing Records vs Indiana

Individual Passing yds game @ Indiana

351 yds by Joe Germaine 31-45 1998 good for 5th beat all time 1998

Passing Attempts @ Indiana

45 by Joe Germaine 31-351 yds good for 4th all time (not currently listed in Record Book, they made an error based on other records).1998

Pass Completions @ Indiana

31 by Joe Germaine 45-351 yds good for 1st place tie. 1998

Passes had intercepted @ Indiana

4 by Greg Frey @Indiana 1998

TD Passes vs Indiana

4 Troy Smith @ Home 2006 good for 4th place tie

2 Passers for 100 yds @ Indiana

2003 Craig Krenzel     272 yds
        Scott McMullen   108 yds

Total Offense game @ Indiana

338 yds Joe Germaine 1998 good for 9th all time

Other Records vs Indiana

All Purpose yds@ Indiana

279 yds Ted Ginn Jr 2005 good for 6th all time

Field Goals Made

5 Bob Atha @ Home 1981 (In the late 1970's as a QB at Worthington High Bob Atha led his team to its first victory over Upper Arlington since the 1930's). good for 1st (tie)

longest field goal made vs Indiana

55 yds by Dan Stultz @ Home in 1997 good for 2nd all time

Tackles made

23 by Tom Cousineau @ Home 1975 good for 6th all time

Tackles for loss

5.0 Jayson Gwinn in 1993 good for 1st (tie)

Interceptions

3 Arnie Chonko @ Home in 1964 good for 1st (tie)

Interception Yds

75 yds Neal Colzie @ IU in 1973 good for 6th
73 yds Ray Griffin @ IU in 1976 good for 7th

Punt Returns

110 yds Tedd Ginn Jr @ IU in 2005 good for 7th all time

OSU 41 IU 10
PSU 27 Ill  17
Iowa 45 ASU 3
MSU 31 UM 27
MIN 34 WIS 31
PU  31  NU 21

Georgia beats LSU 27-24
OU beats Miami (FL)0 35-17
USC beats Cal 27-24
Tennessee beats Auburn 24-17


Bowl Projections

BCS NC    OSU vs OU

ROSE              IOWA vs OREGON/STANFORD
FIESTA          TEXAS  vs ALABAMA
ORANGE        VIRGINIA TECH vs CINCINNATI
SUGAR           FLORIDA vs BOISE STATE